SCHOOL OF LIFE SCIENCES
Life Science
Dr. Md Khurshid Alam Khan
| Designation | : | Associate Professor |
| Nature of Employment | : | Regular |
| Date of Joining | : | 02/09/2013 |
| Qualification | : | M.Sc, PhD |
| Phone | : | 91 7418362723 |
| Email ID | : | khurshid.sls@crescent.education |
| Google Scholar link | : | https://scholar.google.com/citations?user=513jj4sAAAAJ&hl=en&oi=ao |
| Scopus Link | : | https://www.scopus.com/authid/detail.uri?authorId=55550454200 |
| Orcid Id | : | https://orcid.org/0000-0002-3205-0729 |
Educational Background
- Ph.D, Jamia Millia Islamia, 2009
- M.Sc, Aligarh Muslim University 2003
- B.Sc (Hons) Aligarh Muslim University 2000
Teaching and research Experience
- Associate Professor at School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology 2019-till date
- Assistant Professor (Sr.Grade) at School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology 2013-2019
- Postdoctoral Research Fellow at University of Iowa, USA (2012-2013)
- Postdoctoral Research fellow at University of Montana, USA (2009-2012)
Honors and Awards
- Junior Research Fellowship (2004-2006) awarded by the CSIR, India
- Senior Research Fellowship (2006-2009) awarded by the CSIR, India
Research areas:
- Protein Biochemistry and Biophysics,
- Bioinformatics,
- Drug Design and Development
Research outcomes
a. Research grants
Completed: 01
- Start-up Research Grant (Young Scientist), DST – Identifying the molecular basis of peroxidase activity of Peroxiredoxin 6- An Approach for designing antioxidant peptides and inhibitors, 2015- 2018, Rs. 14.3 lakhs
Ongoing :01
- Small Extramural Grants, ICMR, Structure-based Design and Development of Selective New Delhi Metallo beta lactamse-1 Inhibitors to Combat Antibiotic Resistance, 2024 –Ongoing, Rs. 65.2 lakhs
b. Publications
Number of Research Publications
- International journals: 23
- Invited talks delivered: 01
- Patents Published: 01
List of publications
- Arunika Krishnan, Faez Iqbal Khan, Sudarkodi Sukumar, Booja C.S., Mahadev Ota, Md. Khurshid Alam Khan. Inhibition of Mycobacterium tuberculosis Cell Wall Biosynthesis by Repurposing Drugs: Molecular Docking, Simulation, and 3D QSAR. ChemistrySelect, 10(10), e202404932, 2025. (Scopus and WoS indexed, Impact Factor: 3.2) https://doi.org/10.1002/slct.202404932 (Q3)
- Mashihur Rahman, Mohd Ahsan, Md. Tabish Rehman, Mohamed F. AlAjmi, Md. Khurshid Alam Khan. Phytosterols as inhibitors of New Delhi metallo-β-lactamase (NDM-1): an in silico study. Molecular Diversity, 2024. (Scopus and WoS indexed, Impact Factor: 3.2) https://doi.org/10.1007/s11030-024-11020-6 (Q2)
- Arunika Krishnan, Faez Iqbal Khan, Sudarkodi Sukumar, Md. Khurshid Alam Khan. Identification of potential molecular targets and repurposed drugs for tuberculosis using network-based screening approach, molecular docking, and simulation. Journal of Biomolecular Structure and Dynamics, 2023. (Scopus and WoS indexed, Impact Factor: 5.2) https://doi.org/10.1080/07391102.2023.2279699 (Q2)
- Mohd Basheeruddin, Neesar Ahmed, Md. Khurshid Alam Khan, Shazia Jamal. Betaine, an Organic Osmolyte Effectively Counteracts the Deleterious Effect of Diclofenac on Protein Structure and Stability. Biochemistry (Moscow), 68, 356–364, 2023. (Scopus and WoS indexed, Impact Factor: 2.2) https://link.springer.com/article/10.1134/S000635092303003X (Q2)
- Sana Qausain, Faez Iqbal Khan, Md. Khurshid Alam Khan. Conserved acidic second shell residue modulates the structure, stability and activity of non-seleno human peroxiredoxin 6. International Journal of Biological Macromolecules, 242(3), 124796, 2023. (Scopus and WoS indexed, Impact Factor: 8.0) https://doi.org/10.1016/j.ijbiomac.2023.124796 (Q1)
- Faez Iqbal Khan, Md. Tabish Rehman, Fathima Sameena, Tabish Hussain, Mohamed F. AlAjmi, Dakun Lai, Md. Khurshid A. Khan. Investigating the binding mechanism of topiramate with bovine serum albumin using spectroscopic and computational methods. Journal of Molecular Recognition, 35(7), e2958, 2022. (Scopus and WoS indexed, Impact Factor: 2.8) https://doi.org/10.1002/jmr.2958 (Q3)
- Fasil Ali, Usma Manzoor, Faez Iqbal Khan, Dakun Lai, Md. Khurshid A. Khan, K.S. Chandrashekharaiah, L. Rajendrakumar Singh, Tanveer Ali Dar. Effect of polyol osmolytes on the structure-function integrity and aggregation propensity of catalase: A comprehensive study based on spectroscopic and molecular dynamic simulation. International Journal of Biological Macromolecules, 209(A), 198–210, 2022. (Scopus and WoS indexed, Impact Factor: 8.0) https://doi.org/10.1016/j.ijbiomac.2022.04.013 (Q1)
- Gurumayum Suraj Sharma, Snigdha Krishna, Sheeza Khan, Tanveer A. Dar, Md. Khurshid A. Khan, Laishram Rajendrakumar Singh. Protecting thermodynamic stability of protein: The basic paradigm against stress and unfolded protein response by osmolytes. International Journal of Biological Macromolecules, 177, 229–240, 2021. (Scopus and WoS indexed, Impact Factor: 8.0) https://doi.org/10.1016/j.ijbiomac.2021.02.102 (Q1)
- Sana Qausain, Faez Iqbal Khan, Dakun Lai, Md. Imtaiyaz Hassan, Mohd Basheeruddin, Neesar Ahmed, Md. Khurshid A. Khan. Mechanistic insights into the urea-induced denaturation of a non-seleno thiol specific antioxidant human peroxiredoxin 6. International Journal of Biological Macromolecules, 161, 1171–1180, 2020. (Scopus and WoS indexed, Impact Factor: 8.0) https://doi.org/10.1016/j.ijbiomac.2020.05.168 (Q1)
- Ushma Shah, Mohammad Nasiruddin, Sajad Ahmad Dar, Md. Khurshid A. Khan, Mohammad Riyaz Akhter, Ali Rabaan, Shafiul Haque. Emerging biomarkers and clinical significance of HPV genotyping in prevention and management of cervical cancer. Microbial Pathogenesis, 143, 104131, 2020. (Scopus and WoS indexed, Impact Factor: 3.8) https://doi.org/10.1016/j.micpath.2020.104131 (Q1)
- Sudarkodi Sukumar, Krishnan Hajela, Md. Khurshid A. Khan. Protein Kinases as antituberculosis targets: The case of Thymidylate kinases. Frontiers in Bioscience (Landmark Ed), 25, 1636–1654, 2020. (Scopus and WoS indexed, Impact Factor: 3.1) https://doi.org/10.2741/4871 (Q1)
- Mashihur Rahman, Md. Khurshid A. Khan. In silico based unraveling of New Delhi metallo-β-lactamase (NDM-1) inhibitors from natural compounds: a molecular docking and molecular dynamics simulation study. Journal of Biomolecular Structure and Dynamics, 2019. (Scopus and WoS indexed, Impact Factor: 5.2) https://doi.org/10.1080/07391102.2019.1627248 (Q2)
- Thirumurugan D, Vijayakumar R, Vadivalagan C, Karthika P, Alam Khan M.K. Isolation, structure elucidation and antibacterial activity of methyl-4,8-dimethylundecanate from the marine actinobacterium Streptomyces albogriseolus ECR64. Microbial Pathogenesis, 121, 166–172, 2018. (Scopus and WoS indexed, Impact Factor: 3.8) https://doi.org/10.1016/j.micpath.2018.05.025 (Q1)
- Nasser A. Al-Shabib, Fohad Mabood Husain, Iftekhar Hassan, Mohd Shahnawaz Khan, et al., Md. Khurshid A. Khan, Iqbal Ahmad. Biofabrication of Zinc Oxide Nanoparticle from Ochradenus baccatus Leaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, and In Vivo Toxicity and Stress Studies. Journal of Nanomaterials, 2018, Article ID 8612158, 1–14. (Scopus and WoS indexed) https://doi.org/10.1155/2018/8612158 (Q2)
- V. Lavanya, B.A. Kumar, S. Jamal, M.K.A. Khan, N. Ahmed. Sub Micellar concentration of sodium dodecyl sulphate prevents thermal denaturation induced aggregation of Plant Lectin, Jacalin. The Protein Journal, 36(1), 17–27, 2017. (Scopus and WoS indexed, Impact Factor: 4.0) https://doi.org/10.1007/s10930-017-9694-1 (Q3)
- V. Lavanya, Neesar Ahmed, Md. Khurshid A. Khan, Shazia Jamal. Sustained Mitogenic Effect on K562 Human Chronic Myelogenous Leukemia Cells by Dietary Lectin, Jacalin. Glycoconjugate Journal, 33(6), 877–886, 2016. (Scopus and WoS indexed, Impact Factor: 3.0) https://doi.org/10.1007/s10719-016-9725-8 (Q2)
- Levi J. McClelland, Sean M. Seagraves, Md. Khurshid A. Khan, et al. The Response of Ω-Loop D Dynamics to Truncation of Trimethyllysine 72 of Yeast Iso-1-cytochrome c depends on the nature of Loop Deformation. Journal of Biological Inorganic Chemistry, 20, 805–819, 2015. (Scopus and WoS indexed, Impact Factor: 3.8) https://doi.org/10.1007/s00775-015-1267-1 (Q1)
- Hamidur Rahaman, Md. Khurshid A. Khan, Md. Imtaiyaz Hassan, Asimul Islam, Ali Akbar Moosavi-Movahedi, Faizan Ahmad. Heterogeneity of equilibrium molten globule state of cytochrome c induced by weak salt denaturants. PLOS ONE, 10(4): e0120465, 2015. (Scopus and WoS indexed, Impact Factor: 3.7) https://doi.org/10.1371/journal.pone.0120465 (Q1)
- M. Warepam, G.S. Sharma, T.A. Dar, M.K. Khan, L.R. Singh. Structural characteristic of the initial unfolded state on refolding determines catalytic efficiency of the folded protein in presence of osmolytes. PLOS ONE, 9(10): e109408, 2014. (Scopus and WoS indexed, Impact Factor: 3.7) https://doi.org/10.1371/journal.pone.0109408 (Q1)
Book Chapters
- Ilma Shakeel, Yeshfa Zaidi, Varsha Gupta, Sufian Badar, Md Khurshid A. Khan, Bekhzod Abdullaev, Mohammad Afzal, Md Imtaiyaz Hassan, Emerging small-molecule inhibitors of ATM kinase targeting cancer therapy, Academic press, 2022, Book Chapter. https://doi.org/10.1016/B978-0-323-91287-7.00019-3
- Subhamoy Banerjee and Md. Khurshid A. Khan, Calcium calmodulin-dependent protein kinase as a potential drug target, Academic press, 2022, Book Chapter. https://doi.org/10.1016/B978-0-323-91287-7.00001-6
- Sudarkodi Sukumar, Md Zafaryab, Md. Khurshid A. Khan, Krishnan Hajela and Mohammad Nasiruddin Combination anti-tuberculosis therapy: Opportunities and challenges to combat drug resistant tuberculosis, Academic Press, (2020), Book Chapter. https://doi.org/10.1016/B978-0-12-820576-1.00006-0
- Sana Quasain, Hemalatha Srinivasan, Shazia Jamal, Mohammad Nasiruddin and Md. Khurshid A. Khan. Phosphorylation and acetylation as post-translational modification of proteins: Role in human health and associated diseases. Academic Press, (2018) – Book Chapter. https://doi.org/10.1016/B978-0-12-811913-6.00003-5
c. Research guidance
Ph.D
Completed :01
Submitted: 01
Ongoing: 01
List of Scholars Completed
| S.No | Name of the scholar | Title of the theis | Year of registration | year of Completion | Scholarship details | Outcomes |
| 1 | Sana Qausain | Understanding the Structure-Function Relation of Peroxidase Activity of Peroxiredoxin-6 | 2016 | Completed | ICMR | Publications: 02 Conference presentations: 04 |
List of Scholars Submitted
| S.No | Name of the scholar | Title of the theis | Year of registration | year of Completion | Scholarship details | Outcomes |
1 | Mashihur Rahman | Treatment Strategies of NDM-1 Producing Bacteria: Combined Experimental and Bioinformatics Approach | 2014 | Submitted | BSACIST | Publications: 02 Conference presentations: 03 |
List of Scholars Ongoing
| S.No | Name of the scholar | Title of the theis | Year of registration | year of Completion | Scholarship details | Outcomes |
1 | Arunika Krishnan | Genomic Analysis and In silico characterization of Mycobacterium tuberculosis Lineages for Novel Therapeutics | 2019 | Ongoing | BSACIST | Publications: 02 Conference presentations: 03 |
M.Tech
Completed projects: 09 Ongoing projects : 03
| S.No | Name of the student | Title of the project | Year of award | Outcomes |
| 1. | Afaan Ahamed Mohammed Ali | In-Silico Identificaation and analysis of potential inhibitors for Glut3 carrier protein | 2025 | |
| 2. | A.S. Nisha | Virtual Screening of FDA approved drugs for determining potent inhibitors of PIM-1 kinase against prostate cancer. | 2023 | |
| 3. | R. Nimitha | Interactome analysis of Staphylococoucs aureus in bovine mastitits- An in silico approach | 2023 | |
| 4. | R. Krishnan | Interactome analysis of Mycobacterium tuberculosis cell wall biosynthesis proteins- An in silico approach | 2023 | |
| 5. | R. Krishna G | Identifying key inhibitors of PDK3 protein using in silico studies | 2023 | |
| 6. | Sri Vansunthra | Repurposing FDA approved drugs as potential inhibitors against Rho associated protein kinase -1 | 2023 | |
| 7. | C S Booja | Drug repurposing for Mycobacterium tuberculosis with the protein embB: Virtual screening, binding free energy and molecular docking | 2023 | |
| 8. | Vishal Sanskriti | Identifying key inhibitors of ATP binding cassette subfamily G member-2(ABCG2) protein using in silico studies | 2023 | |
| 9. | V. Nivedita | Mitigation of antimicrobial resistance by E-peroxone process | 2022 |
B.Tech
Completed projects: 17 Ongoing projects : 04
| S.No | Name of the student | Title of the project | Year of award | Outcomes |
| 1. | Noor Hammna Anwardeen | Design and Optimization of Peptide-Based Inhibitors Targeting New Delhi Metallo-beta-lactamase-1 | 2025 | Conference presentations:01 |
| 2. | Mohammed Maaz M | Identification and Development of phytocompound and its derivative Targeting E. coli DHFR to Combat Multidrug Resistance | 2025 | Conference presentations:01 |
| 3. | V Adhitya | An Investigation of the binding interactions between rasagiline and bovine serum albumin using computational and multispectroscopic methods | 2025 | Conference presentations:01 |
| 4. | Naseem Meera A | Tatrgeting Folate synthesis: Exploring petide inhibitors against E. Coli Dihydrofolate reductase. | 2025 | Conference presentations:01 |
| 5. | Karthik K | Repurposing Isoliquiririn and its derivatives to inhibit the catalytic activity of New delhi Metallobetalactamase-I | 2025 | Conference presentations:01 |
| 6. | Kulsum Zehra N | Effect of Granulocyte-colonystimulating factor on ECM-related gene expression in Human Dermal fibrobalsts | 2025 | |
| 7. | Md Ismail kareem | Bovine serum albumin as a biocompatible carrier for controlled release of Clinidipine using computational and multispectroscopic methods | 2025 | Conference presentations:01 |
| 8. | Zainab S. Zafar | Targeting Loop 3 of NDM-1: Design and Development of inhibitors to inhibit Catalytic activity | 2023 | Conference presentations:01 |
| 9. | S. Varsha | In silico virtual screening of FDA-approved drugs against Dihydrofolate reductase (DHFR) of Plasmodiumfalciparum | 2024 | Conference presentations:01 |
| 10. | SHINOZ T | Virtual screening and drug repurposing to identify potential inhibitors against Mycobacterium tuberculosis thymidylatesynthase(thya) | 2024 | Conference presentations: 01 |
| 11. | RONISHA S | Multi-protein target approach to identify potential cannabinoids againstlungcancer | 2024 | Conference presentations:01 |
| 12. | Mohamed Danish. K R | Virtual screening of fda approved drugs for potential inhibitors against mcr-1 of klebsiellapneumoniae | 2024 | Conference presentations:01 |
| 13. | Meganathan B | Identification of FDA approved drugs against histone acetylase kat7 (7d0o) of homo sapiens using virtual screeningapproach | 2024 | Conference presentations:01 |
| 14. | Hameeda Banu | Identifying potential inhibitors against Mycobacterium tuberculosis Transcription Factor EmbR through virtualscreening | 2024 | Conference presentations:01 |
| 15. | AravindhaN. V | Virtual Screening and repurposing of FDA- approved drugs against bacterialNDM-12 | 2024 | Conference presentations:01 |
| 16. | Abinesh v | Virtual screening and Drug repurposing of potential inhibitors against the Mycobacterium tuberculosis cytochrome bc1 complex cytochromecsubunit | 2024 | Conference presentations:01 |
| 17. | J. Sakthivel | Recycling of cigarette butts for cleaner environment | 2023 |
