DEPARTMENT OF LIFE SCIENCE
Life Science
Dr. Md Khurshid Alam Khan
| Designation | : | Associate Professor |
| Nature of Employment | : | Regular |
| Date of Joining | : | 02/09/2013 |
| Qualification | : | M.Sc, PhD |
| Email ID | : | khurshid.sls@crescent.education |
| Google Scholar link | : | https://scholar.google.com/citations?user=513jj4sAAAAJ&hl=en&oi=ao |
| Scopus Link | : | https://www.scopus.com/authid/detail.uri?authorId=55550454200 |
| Orcid Id | : | https://orcid.org/0000-0002-3205-0729 |
Educational Background
- Ph.D, Jamia Millia Islamia, 2009
- M.Sc, Aligarh Muslim University 2003
- B.Sc (Hons) Aligarh Muslim University 2000
Teaching and research Experience
- Associate Professor at School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology 2019- till date
- Assistant Professor (Sr.Grade) at School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology 2013-2019
- Postdoctoral Research Fellow at University of Iowa, USA (2012-2013)
- Postdoctoral Research fellow at University of Montana, USA (2009-2012)
Honors and Awards
- Junior Research Fellowship (2004-2006) awarded by the CSIR, India
- Senior Research Fellowship (2006-2009) awarded by the CSIR, India
Research areas:
- Protein Biochemistry and Biophysics
- Bioinformatics
Research outcomes
a. Research grants
Completed: 01
- Start-up Research Grant (Young Scientist), DST-SERB, Government of India, Identifying the molecular basis of peroxidase activity of Peroxiredoxin 6- An Approach for designing antioxidant peptides and inhibitors, Rs. 14.3 lakhs
b. Publications
Number of Research Publications
- International journals: 19
- Invited talks delivered: 01
- Patents Published: 01
List of publications
- Sana Qausain, Faez Iqbal Khan, Md Khurshid Alam Khan. Conserved acidic second shell residue modulates the structure, stability and activity of non-seleno human peroxiredoxin 6. International Journal of Biological Macromolecules (2023) Volume 242, Part 3, 124796 (Scopus and WoS indexed)(Impact factor-8.0) https://doi.org/10.1016/j.ijbiomac.2023.124796
- Faez Iqbal Khan, Md Tabish Rehman, Fathima Sameena, Tabish Hussain, Mohamed F AlAjmi, Dakun Lai, Md Khurshid A. Khan. Investigating the binding mechanism of topiramate with bovine serum albumin using spectroscopic and computational methods. Journal of Molecular Recognition (2022) Volume 35, issue 7, e2958. (Scopus and WoS indexed)(Impact factor-2.8) https://doi.org/10.1002/jmr.2958
- Fasil Ali, Usma Manzoor, Faez Iqbal Khan, Dakun Lai, Md Khurshid A. Khan, K.S. Chandrashekharaiah, L. Rajendrakumar Singh and Tanveer Ali Dar. Effect of polyol osmolytes on the structure-function integrity and aggregation propensity of catalase: A comprehensive study based on spectroscopic and molecular dynamic simulation. International Journal of Biological Macromolecules (2022) Volume 209, Part A, Pages 198-210. (Scopus and WoS indexed)(Impact factor-8.0) https://doi.org/10.1016/j.ijbiomac.2022.04.013
- Gurumayum Suraj Sharma, Snigdha Krishna, Sheeza Khan, Tanveer A.Dar, Md. Khurshid A.Khan, Laishram Rajendrakumar Singh. Protecting thermodynamic stability of protein: The basic paradigm against stress and unfolded protein response by osmolytes, International Journal of Biological Macromolecules (2021), 177, 229-240 (Scopus and WoS indexed) (Impact factor-8.0) https://doi.org/10.1016/j.ijbiomac.2021.02.102
- Sana Qausain, Faez Iqbal Khan, Dakun Lai, Md. Imtaiyaz Hassan, Mohd Basheeruddin, Neesar Ahmed and Md. Khurshid A. Khan. Mechanistic insights into the urea-induced denaturation of a non-seleno thiol specific antioxidant human peroxiredoxin 6, International Journal of Biological Macromolecules (2020). 161, 1171-1180 (Scopus and WoS indexed)(Impact factor-8.0) https://doi.org/10.1016/j.ijbiomac.2020.05.168
- Ushma Shah, Mohammad Nasiruddin, Sajad Ahmad Dar, Md. Khurshid A. Khan, Mohammad Riyaz Akhter, Ali Rabaan and Shafiul Haque. Emerging biomarkers and clinical significance of HPV genotyping in prevention and management of cervical cancer. Microbial pathogenesis, (2020) Volume 143, 104131 (Scopus and WoS indexed)(Impact factor-3.8) https://doi.org/10.1016/j.micpath.2020.104131
- Sudarkodi Sukumar, Krishnan Hajela and Md. Khurshid A. Khan. Protein Kinases as antituberculosis targets: The case of Thymidylate kinases, Front Biosci (Landmark Ed) (2020), 25, 1636-1654. (Scopus and WoS indexed)(Impact factor-3.11) https://doi.org/10.2741/4871
- Mashihur Rahman and Md. Khurshid A. Khan. In silico based unraveling of New Delhi metallo-β- lactamase (NDM-1) inhibitors from natural compounds: a molecular docking and molecular dynamics simulation study, Journal of Biomolecular and Structural Dynamics, (2019) (Scopus and WoS indexed) (Impact factor-5.23) https://doi.org/10.1080/07391102.2019.1627248
- Thirumurugan D, Vijayakumar R, Vadivalagan C, Karthika P, Alam Khan MK. Isolation, structure elucidation and antibacterial activity of methyl-4,8-dimethylundecanate from the marine actinobacterium Streptomyces albogriseolus ECR64. Microbial Pathogenesis, (2018) 121:166-172. (Scopus and WoS indexed)(Impact factor-3.8) https://doi.org/10.1016/j.micpath.2018.05.025
- Nasser A. Al-Shabib, Fohad Mabood Husain, Iftekhar Hassan, Mohd Shahnawaz Khan, Faheem Ahmed, Faizan Abul Qais, Mohammad Oves, Mashihur Rahman, Rais Ahmad Khan, Altaf Khan, Afzal Hussain, Ibrahim M. Alhazza, Shazia Aman, Saba Noor, Hossam Ebaid, Jameel Al-Tamimi, Javed Masood Khan, Abdul Rehman M. Al-Ghadeer, Md Khurshid A. Khan, and Iqbal Ahmad Biofabrication of Zinc Oxide Nanoparticle from Ochradenus baccatus Leaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, and In Vivo Toxicity and Stress Studies. Journal of Nanomaterials, (2018), Volume 2018, 1-14. (Scopus and WoS indexed) https://doi.org/10.1155/2018/8612158
- V Lavanya, BA Kumar, S Jamal, MKA Khan & N Ahmed. Sub Micellar concentration of sodium dodecyl sulphate prevents thermal denaturation induced aggregation of Plant Lectin, Jacalin. The Protein Journal (2017) 36 (1), 17-27. Journal of Nanomaterials, (2018), Volume 2018, 1-14. (Scopus and WoS indexed) (Impact factor-4.0) https://doi.org/10.1007/s10930-017-9694-1
- V. Lavanya, Neesar Ahmed, Md Khurshid A. Khan & Shazia Jamal. Sustained Mitogenic Effect on K562 Human Chronic Myelogenous Leukemia Cells by Dietary Lectin, Jacalin. Glycoconjugate Journal (2016), Volume 33, Issue 6, pp 877-886. (Scopus and WoS indexed) (Impact factor-3.0) https://doi.org/10.1007/s10719-016-9725-8
- Levi J. McClelland, Sean M. Seagraves, Md. Khurshid A. Khan, Melisa M. Cherney, Swati Bandi, Justin E. Culbertson and Bruce E. Bowler The Response of Ω-Loop D Dynamics to Truncation of Trimethyllysine 72 of Yeasr Iso-1- cytochrom depends on the nature of Loop Deformation. J Biol Inorg Chem. (2015). 20:805-819. (Scopus and WoS indexed) (Impact factor-3.8) https://doi.org/10.1007/s00775-015-1267-1
- Hamidur Rahaman, Md. Khurshid A. Khan, Md. Imtaiyaz Hassan, Asimul Islam, Ali Akbar Moosavi- Movahedi and Faizan Ahmad. Heterogeneity of equilibrium molten globule state of cytochrome c induced by weak salt denaturants. Plos One (2015) 10(4):e0120465 (Scopus and WoS indexed) (Impact factor-3.7) https://doi.org/10.1371/journal.pone.0120465
- M. Warepam, G. S. Sharma, T. A. Dar TA, M. K. Khan and L. R. Singh Structural characteristic of the initial unfolded state on refolding determines catalytic efficiency of the folded protein in presence of osmolytes. Plos One (2014) 14; 9(10):e109408. (Scopus and WoS indexed) (Impact factor-3.7) https://doi.org/10.1371/journal.pone.0109408
- Ilma Shakeel, Yeshfa Zaidi, Varsha Gupta, Sufian Badar, Md Khurshid A. Khan, Bekhzod Abdullaev, Mohammad Afzal, Md Imtaiyaz Hassan, Emerging small-molecule inhibitors of ATM kinase targeting cancer therapy, Academic press, 2022, Book Chapter. https://doi.org/10.1016/B978-0-323-91287-7.00019-3
- Subhamoy Banerjee and Md. Khurshid A. Khan, Calcium calmodulin-dependent protein kinase as a potential drug target, Academic press, 2022, Book Chapter. https://doi.org/10.1016/B978-0-323-91287-7.00001-6
- Sudarkodi Sukumar, Md Zafaryab, Md. Khurshid A. Khan, Krishnan Hajela and Mohammad Nasiruddin Combination anti-tuberculosis therapy: Opportunities and challenges to combat drug resistant tuberculosis, Academic Press, (2020), Book Chapter. https://doi.org/10.1016/B978-0-12-820576-1.00006-0
- Sana Quasain, Hemalatha Srinivasan, Shazia Jamal, Mohammad Nasiruddin and Khurshid A. Khan. Phosphorylation and acetylation as post-translational modification of proteins: Role in human health and associated diseases. Academic Press, (2018) – Book Chapter. https://doi.org/10.1016/B978-0-12-811913-6.00003-5
c. Research guidance
Ph.D
Ongoing: 03
List of Scholars ongoing
| S.No | Name of the scholar | Title of the theis | Year of registration | Year of completion | Scholarship details | Outcomes |
|---|---|---|---|---|---|---|
| 1 | Mashihur Rahman | Treatment Strategies of NDM-1 Producing Bacteria: Combined Experimental and Bioinformatics Approach | 2014 | Ongoing | BSACIST | Publications: 01 Conference presentations: 04 Patent:00 Sequence:00 |
| 2 | Sana Qausain | Understanding the Structure-Function Relation of Peroxidase Activity of Peroxiredoxin-6 | 2016 | Ongoing | ICMR | Publications: 02 Conference presentations: 03 Patent:00 Sequence:00 |
| 3 | Arunika Krishnan | Genomic Analysis and In silico characterization of Mycobacterium tuberculosis Lineages for Novel Therapeutics | 2019 | Ongoing | BSACIST | Publications: 01 Conference presentations: 03 Patent:00 Sequence:00 |
M.Tech
Completed projects: 08; ongoing projects: 01
| S.No | Name of the student | Title of the project | Year of award | Outcomes |
|---|---|---|---|---|
| 1 | V. Nivedita | Mitigation of antimicrobial resistance by E-peroxone process | 2022 | Publications: 0 Communicated:0 Conference presentations:0 Start-up: 0 |
| 2 | A.S. Nisha | Virtual Screening of FDA approved drugs for determining potent inhibitors of PIM-1 kinase against prostate cancer. | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
| 3 | R. Nimitha | Interactome analysis of Staphylococoucs aureus in bovine mastitits- An in silico approach | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
| 4 | R. Krishnan | Interactome analysis of Mycobacterium tuberculosis cell wall biosynthesis proteins- An in silico approach | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
| 5 | R. Krishna G | Identifying key inhibitors of PDK3 protein using in silico studies | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
| 6 | Sri Vansunthra | Repurposing FDA approved drugs as potential inhibitors against Rho associated protein kinase -1 | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
| 7 | C S Booja | Drug repurposing for Mycobacterium tuberculosis with the protein embB: Virtual screening, binding free energy and molecular docking | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
| 8 | Vishal Sanskriti | Identifying key inhibitors of ATP binding cassette subfamily G member-2(ABCG2) protein using in silico studies | 2023 | Publications: 0communicated:0 Conference presentations:0 Start-up:0 |
B.Tech
Completed projects: 1 ongoing projects: 06
| S.No | Name of the student | Title of the project | Year of award | Outcomes |
|---|---|---|---|---|
| 1 | J. Sakthivel | Recycling of cigarette butts for cleaner environment | 2023 | Publications: 0 communicated:0 Conference presentations:0 Start-up: 0 |
