Dr. S. Yuvaraj

Education

Work Experience

Lecture Courses

• Pharmaceutical Chemistry

Research

Projects supervised

UG : 4

Area of Research Interest

• Synthesis of Heterocyclic moiety as Bioactive compounds
• Computer Aided Drug Design
• Spectroscopic Analysis of Drugs and molecules
• Isolation and purification of natural products
• Therapeutic agents for Metabolic disorder, Cancer and Inflammation

Publication

• Kumar BP, Yuvaraj S, Srivastava A, Chaturvedi V, Manju YK, Suresh B, Nanjan MJ. CoMFA study, syntheses, antitubercular and anticancer activity of some novel 1, 4-dihydropyridines. Letters in Drug Design & Discovery. 2008 Jan 1;5(1):7-14. Impact factor 1.15
• Justin A, Mandal S, Prabitha P, Dhivya S, Yuvaraj S, Kabadi P, Sekhar SJ, Sandhya CH, Wadhwani AD, Divakar S, Bharathi JJ. Rational design, synthesis, and in vitro neuroprotective evaluation of novel glitazones for PGC-1α activation via PPAR-γ: a new therapeutic strategy for neurodegenerative disorders. Neurotoxicity research. 2020 Mar;37(3):508-24. Impact factor 3.82.
• Srinivas MG, Prabhakaran P, Mandal SP, Sivamani Y, Guddur P, Kumar BR. Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies. Letters in Drug Design & Discovery. 2020 Jun 1;17(7):840-9. Impact factor 1.15.
• Mandal SP, Reji A, Bhavimani G, Prabitha P, Durai P, Yuvaraj S, Shashank A, Krishna KL, Kumar BP. Rational Design, Synthesis and Evaluation of Novel Rodanine Derivatives for Antihyperglycemic Activity. Polycyclic Aromatic Compounds. 2020 Aug 30:1-2. Impact factor 2.13.
• Justin A, Ashwini P, Jose JA, Jeyarani V, Dhanabal SP, Manisha C, Mandal SP, Bhavimani G, Prabitha P, Yuvaraj S, Prashantha Kumar BR. Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model. Frontiers in Neuroscience. 2020:992. Impact factor 4.50.
• Kumar BP, Kumar AP, Jose JA, Prabitha P, Yuvaraj S, Chipurupalli S, Jeyarani V, Manisha C, Banerjee S, Jeyabalan JB, Mohankumar SK. Minutes of PPAR-γ agonism and neuroprotection. Neurochemistry International. 2020 Nov 1;140:104814. Impact factor 4.29.
• Krithika U, Prabitha P, Mandal SP, Yuvaraj S, Priya D, Wadhwani AD, Prashantha Kumar BR. Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study. Medicinal Chemistry. 2021 Mar 1;17(3):216-29. Impact factor 2.01.
• Sivamani Y, Shanmugarajan D, Kumar TD, Faizan S, Channappa B, Naishima NL, Kumar BP. A promising in silico protocol to develop novel PPARγ antagonists as potential anticancer agents: Design, synthesis and experimental validation via PPARγ protein activity and competitive binding assay. Computational biology and chemistry. 2021 Dec 1;95:107600. Impact factor 3.73.
• Yuvaraj S, Kumar BP. Peroxisome proliferator-activated receptor-γ as a novel and promising target for treating cancer via regulation of inflammation: A brief review. Mini-reviews in medicinal chemistry. 2022 Jan 1;22(1):3-14. Impact factor 3.86.
• Faizan S, Roohi TF, Raju RM, Yuvaraj S, Kumar BP. A Century-Old One-Pot Multicomponent Biginelli Reaction Products Still Finds a Niche in Drug Discoveries: Synthesis, Mechanistic studies and Diverse Biological Activities of Dihydropyrimidines. Journal of Molecular Structure. 2023 Jun 16:136020. Impact factor 3.84
• Yuvaraj Sivamani, Ankan Chakraborty, Dhruv Rao, Nabh Chandra, Sumitha Elayaperumal. Herbal Plants and its implication in Brain Stroke. African Journal of Biological Sciences. 6(5) (2024). 6364-6373. Impact factor 1.0.
• Sumitha Elayaperumal, Yuvaraj Sivamani, P S. Kavya S, Jagadeep Chandra. Screening of bacteria from vegetable waste for evaluation of pectinase activity and its application in juice clarification. African Journal of Biological Sciences. 6(5) (2024). 8196-8208. Impact factor 1.0.
• Faizan S, Wali AF, Talath S, Rehman MU, Sivamani Y, Nilugal KC, Shivangere NB, Attia SM, Nadeem A, Elayaperumal S, Kumar BP. Novel Dihydropyrimidines as Promising EGFR & HER2 Inhibitors: Insights from Experimental and Computational Studies. European Journal of Medicinal Chemistry. 2024 Jun 19:116607. Impact factor 6.0.

Participation in conferences/Seminars/Workshops

• Quality Improvement Program Conducted on “Modern Trends in Pharmaceutical Chemistry” at JSS College of Pharmacy, Ootacamund.
• Workshop on Environment & Pollution Awareness”, at JSS College of Pharmacy Ooty, sponsored by All India Council of Technical Education,
• Seminar on Career Prospects In Pharmacy Profession”, Organized by The Indian Pharmaceutical Association (Education Division), Ootacamund.
• “International Conference on Health Sciences”, Organized by JSS Mahavidyapeetha, Mysore, Karnataka.
• National Conference on Advances in Pharmaceutical Sciences”, Organized by KMCH College of Pharmacy, Coimbatore, during June 30th 2005.
• Workshop on using Zotero (reference manager software)”, Organized by Clinical Epidemiology Unit, Christian Medical College, Vellore.
• Workshop on using Epi-Data (database creation software)”, Organized by Clinical Epidemiology Unit, Christian Medical College, Vellore.
• Workshop on research ethics and Good Clinical Practice (GCP) Guidelines, Organized by Christian Medical College, Vellore
• Workshop on JMP Software for Statistical Discovery, Organized by JSS Academy of Higher Education Research, Mysuru.