Dr. Irfan Navabshan

Teaching

Education

Teaching / Research / Industrial Experience

Lecture Courses

• Pharmaceutical Organic Chemistry
• Pharmaceutical Analysis
• Medicinal Chemistry
• Instrumental Methods of Analysis
• Computer Aided Drug Design
• Biostatistics and Research Methodology

Research

Area of Research Interest

• Synthesis and characterization of bioactive molecules.
• Advanced extraction and separation techniques.
• SBDD, LBDD, Pharmacophore, QSAR, ADMET, Network Pharmacology, QM/MD simulation
• Nano Technology and advanced drug delivery.
• Method development and validation of API
• Invitro, In vivo activity studies

Patents Published

Certified Courses

• Protein modeling and rational Drug design, GVK Biolabs-Hyderabad 2009.
• Medicinal Chemistry – National Program on Technology Enhanced Learning-April-2019.
• Computer-Aided Drug Design – National  Program on  Technology  Enhanced  Learning- September 2019.

Honors and Achievements

• First rank awardee by Tamil Nadu Pharmaceutical Welfare Trust for the M. Pharm project by Honorable Dr. K. Rosaiah, Governor of Tamil Nadu – 2012.
• Best oral Presentation award- International Conference on Biotechnology and Nanotechnology- School of Life Science- Crescent Institute of Science and Technology- Chennai- 30th September 2019.
• Guest lecture -Drug design and development in Microbiology Prince Shri Bhavini Arts & Science College Chennai on 03rd Feb 2020.
• B.S Abdur Rahman research incentive award 2020 for quality publication
• Chaired person- International Conference on recent trends in Biotechnology, Energy, and      Environment, School of Life Science, B.S Abdur Rahaman Crescent Institute of Science and Technology, Chennai. On 18th Feb 2020.
• Jury member in the evaluation of national-level COVID-19 APP/WEB development Hackathon-2019, Anna University, Tiruchirappalli, Tamilnadu, India.
• Guest Lecture on Interactions of Chemicals and Biological System-KPR Institute of Engineering and Technology, Coimbatore-19.05.2022.
• B.S Abdur Rahman research incentive award 2021 and 2022 for quality publications.
• Convener of 45th Indian Social Science Congress,  B.S Abdur Rahaman Crescent Institute of Science and Technology, Chennai – February 28th – March 4th, 2022.
• Special talk for the students of the University of East Landon, Uk during ‘Six weeks Turing Scheme Study Mobility Exchange Program School of Life Science, B.S Abdur Rahaman Crescent Institute of Science and Technology, Chennai – 04.07.2022 – 13.08.2022
• Certificate of merit-world Pharmacist Day 2022, B.S Abdur Rahman Crescent Institute of Science and Technology, 29&30 September 2022.
• Certificate of Appreciation, Medical and first aid team, All India Inter-University ball badminton women tournament, B.S Abdur Rahman Crescent Institute of Science and Technology, January 27, 2023.

Extension Activities

• PROJECT- Bioisosteric replacements of Hepatotoxicity producing fragment in anti-cancer drugs- BIOSOLVE IT- challenge 2019 – Germany.
• Development of strip-based blood  grouping  kit –  BSA Crescent Institute of Science and Technology, Vandalur, Chennai – 600048.

Guideship

• Mohamed Ahadu Shareef TH, Mohamed Divan Masood M, Irfan Navabshan, Biochemical Evaluation of Indus Viva I Pulse Natural Ayurvedic Syrup And It’s In Silico – Interaction Analysis, Asian Journal of Pharmaceutical and Clinical Research, Vol 16, Issue 12, 2023.
• Radhakrishnan, L., Dani, R., Navabshan Irfan. Targeting Aminoglycoside Acetyltransferase Activity of Mycobacterium tuberculosis (H37Rv) Derived Eis (Enhanced Intracellular Survival) Protein with Quercetin. Protein J (2023). https://doi.org/10.1007/s10930-023-10165-x
• S. Mohammed Zaidh, Kiran Balasaheb Aher, Girija Balasaheb Bhavar, N. Irfan, Haja Nazeer Ahmed, Y. Ismail, Genes adaptability and NOL6 protein inhibition studies of fabricated flavan-3-ols lead skeleton intended to treat breast carcinoma, International Journal of Biological Macromolecules, 2023, 127661, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2023.127661
• Durability and microstructure studies of styrene acrylate co-polymer modified ready-mix concrete, Journal of Structural Engineering, Vol. 49, No. 5, December 2022 – January 2023 pp. 358-372.
• Active and allosteric site binding MM-QM studies of Methylidene tetracyclo derivative in PCSK9 protein intended to make a safe antilipidemic agent, Journal of Biomolecular Structure and Dynamics, (2023) DOI: 10.1080/07391102.2023.2239928.
• In Silico and In Vitro Investigation of Phytochemicals Against Shrimp AHPND Syndrome Causing PirA/B Toxins of Vibrio parahaemolyticus. Appl Biochem Biotechnol (2023). https://doi.org/10.1007/s12010-023-04458-1.
• Is Daclatasvir a suitable substitute for Amphotericin B in the treatment of Mucormycosis when Amphotericin B is scarce? Current Drug Research Reviews, Vol 15, I, B -E DOI: 10.2174/2589977515666230430004013.
• A perspective into”TEL” – Tenofovir, Emtricitabine, and Lamivudine antileprotic activities by drug repurposing and exploring the possibility of combination chemotherapy with drug-rescued molecules for a leprosy free mankind. Recent Advances in Anti-infective Drug Discovery. 2023 Feb. DOI: 10.2174/2772434418666230220123217. PMID: 36803758.
• An investigation of algal peptides to target protein of lower respiratory tract infections: In silico approach. Biocatalysis and agricultural Biotechnology, Volume 47. https://doi.org/10.1016/j.bcab.2022.102585.
• Bioisosteric replacements of tyrosine kinases inhibitors to make potent and safe chemotherapy against malignant cells, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2022.2146751.
• Neuroprotective effects of phenolic glycosides from Populus tomentiglandulosa roots in HT22 mouse hippocampal neuronal cells, Journal of Molecular Structure, Volume 1276, 2023, 134685. IF 3.81
• Evaluation of analgesic, anti-inflammatory, and antipyretic activities of Ziziphus mauritania Lam leaves in animal models, Pharmacological Research – Modern Chinese Medicine, 2022, 100153, https://doi.org/10.1016/j.prmcm.2022.100153. Impact factor 10.33
• Virtually screened novel sulfathiazole derivatives as a potential drug candidate for methicillin-resistant Staphylococcus aureus and multidrug-resistant tuberculosis, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2022.2079002. Impact factor 5.235.
• Bioinformatics strategies for studying the molecular mechanisms of fungal extracellular vesicles with a focus on infection and immune responses. Brief Bioinform. 2022 Jul 6:bbac250. DOI: 10.1093/bib/bbac250. Impact Factor 11.62.
• An evidence of bio-adsorption of acid blue dye using neem cake powder: A natural approach for water treatment, Biocatalysis and Agricultural Biotechnology, Volume 42, 2022, 102379.
• Marine biome-derived secondary metabolites, a class of promising antineoplastic agents: A systematic review on their classification, mechanism of action and future perspectives, Science of The Total Environment, 836,2022. Impact factor:10.753.
• Development Characterization and Molecular Simulation studies of Metoclopramide HCl and Tramadol HCl Bilayer Tablets, Research Journal of Pharmacy and Technology. 2022; 15(2):529-4
• In Silico Protein‑Protein Interaction of Pterois volitans Venom with Cancer Inducers of Helicobacter pylori. Appl Biochem Biotechnol. 2021 Nov 29. DOI: 10.1007/s12010-021-03763-x.
• Assessing the Molecular Interaction between PolyLactic-co-glycolic Acid (PLGA) 50:50 and Poly Ethylene Glycol in Presence of Diethyl Phthalate Using in silico Study – A Novel Approach of Pre-Formulation Study. Journal of Pharmaceutical Research International. 3(52B): 144-150, 2021.
• Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain. Appl Biochem Biotechnol. 2021 OCT 26. DOI: 10.1007/s12010-021-03721-7
• Study on the interaction of algal peptides on virulence factors of Helicobactor pylori: In silico Approach. Appl Biochem Biotechnol. 2021 Nov 11, pg 1-17.   
• Evidence of microalgal peptides to target spike protein of COVID-19: In silico approach, doi.org/10.1016/j.micpath.2021.105189. Impact Factor-3.985.
• Computational Lock and Key and Dynamic Trajectory Analysis of Natural Biophors Against COVID-19 Spike Protein to Identify Effective Lead Molecules, Mol Biotechnol 2021 Jun 22;1-11. Impact Factor-2.695.
• In silico Screening and Identification of Natural Compound Sophoraflavanone G as Potential Human Sodium-Glucose Cotransporter 2 Inhibitor, Biointerfaceresearch.2021, Volume 11, Issue 6, 2021, 14173 – 14184.
• Molecular Docking and Experimental Evaluation of Antiulcerogenic Effect of Salvia Fruticosa, Linguistica Antverpiensia, 2021 Issue-2, Pg 91 – 106. Impact Factor-0.5.
• Synthesis and biological evaluation of virtually designed fluoroquinolone analogs against fluoroquinolone-resistant   Escherichia coli intended for   UTI   treatment.   NJC,   2020, 44(31), 13308. Impact Factor-3.288.
• Identification of   Silver   Nanoparticle-shaping   Tridax procumbens   Phytoconstituent by Theoretical Simulation and Experimental Correlation. Indian J. Pharm. Sci. 2019- Vol. 81, Issue 5, pp 900. Impact Factor – 0.630
• Conceptual design of hybrid PCSK9 lead inhibitors against coronary artery disease, biocatalysis, and Agricultural Biotechnology, Vol- 17, 2019, 427-440. Impact Factor – 2.140
• A novel class of tyrosine derivatives as dual 5-LOX and COX-2/mPGES1 inhibitors with PGE2 mediated anticancer properties. NJC, 2019, 43, 834-846. Impact Factor-3.288.
• Molecular Dynamics Studies on COX-2 Protein-tyrosine Analogue Complex and Ligand-based Computational Analysis of Halo-substituted Tyrosine Analogues. LDDD, 2019, 16 (11), 1211-1232. Impact Factor – 1.169.
• Design and virtual screening of novel fluoroquinolone analogs as effective mutant DNA GyrA inhibitors against urinary tract infection causing fluoroquinolone resistant Escherichia coli. RSC Adv.,2018, 8,2362. Impact Factor-3.070.
• Advancement of total phytoconstituent extraction process by new way factor Analysis for Tridax procumbens L. Int. Res. J. of Pharmacy 2017(810):167-173.
• 3-D structural interactions and quantitative structural toxicity studies of tyrosine derivatives intended for safe potent inflammation treatment. CCJ 10, 24 (2016). Impact Factor-2.090
• Antioxidant and in vitro anti-inflammatory activities of Urechites lutea leaves. Int. J. Res. in pharmacology and pharmacotherapeutics, 2016 (77-83).
• Insilco molecular interaction studies of chiral heterocyclic analogs of SAHA as selective Histone Deacetylase 8 inhibitors. LDDD, 2015,12 (9), 711 – 727. Impact Factor – 1.169.
• Design synthesis characterization and dual biological activity of some novel morphanthridine earth6,11 dione derivatives. BioMedRx., 2013, 1(1), 68-73.
• QSAR model for identifying new active molecules against human phospholipase A2 enzyme. Int.Res J Pharm. App Sci., 2012; 2(2):57-64.

Book Chapters

1. Computer Applications in Drug Discovery and Development 2018.EISBN13: 9781522573272.

– Molecular Modelling Studies of Novel Cox -2 Inhibitors
– Computational Investigation of Versatile Activity of Piperine.

Conference / Seminar / Workshop

• National symposium on Anti-tuberculosis drug discovery: current status and prospects. 30 October 2010. Department of bacteriology, TBRC, Chennai-31.
• National seminar on the current scenario in Pharma Education. 4th January 2011, Adhiparasakthi College of Pharmacy, Chennai.
• Poster presented at the 7th International Symposium on current trends in pharmaceutical sciences: Advances in new drug discovery and development. Zydus, Ahmedabad. India.
• Lecture on “how to do a good Ph. D. thesis”. Anna University, Chennai.
• National level lecture workshop on “Plant tissue culture and phytochemistry” (2018) School of Life sciences, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
• National level conference on “ Recent advances in plant sciences: Towards food safety and food security” (2018) School of Life sciences, Bharathidasan University, Tiruchirappalli, Tamilnadu, India.
• International conference on emerging areas of biotechnology for human welfare and bio entrepreneurship. September 11 & 12, 2018, crescent institute of science and technology, Vandalur, Chennai – 600048 Tamil Nadu, India.
• International Symposium on Streamlining  Drug  Design,  22-02-2019,  Zastra  Innovations, Bangalore.
• National seminar on e-learning and MOOCs in Higher Education organized by Guru Angad Dev Teaching Learning Center of MHRD, IN Crescent Institute of Science and Technology, Chennai. 9th   March 2019.
• National Programme on Technology Enhanced Learning- workshop-computer aided drug design Department of Biotechnology, IITM, 13th September 2019.
• International Conference on Biotechnology and Nanotechnology- School Life Science-Crescent Institute of Science and Technology-Chennai-30th   September 2019.
• Seminar on  Computational  Methods in  Chemistry and  Physics of  Materials-Department of Chemistry, B.S Abdur Rahaman Crescent Institute of Science and Technology, Chennai on 28 & 29th November 2019.
• International conference on applications   Biotechnology and   Nanotechnology,   School of LifeScience, B.S Abdur Rahaman Crescent Institute of Science and Technology, Chennai on 30th Sep 2019.
• City Camp: Essentials of Scientific Entrepreneurship-BIRAC Regional Bio-innovation Center, Crescent Innovation and Incubation Council-May2019.
• Current Trends and Challenges in Pharmaceutical Sciences Indo-Malaysian Conference-2019, Santhiram College of Pharmacy, Andhra Pradesh -August 2019 
• International Seminar on Frontiers in Chemistry-2020 Department of Chemistry, B.S Abdur Rahman Crescent Institute of Science and Technology, Chennai on 7th Jan 2020.
• National Conference on Innovation in Novel drug Delivery systems and clinical Research-P. Reddy Memorial College of Pharmacy, Andhra Pradesh, January 2020.
• 60th National Pharmacy Week -2021, Certificate of Appreciation- B.S Abdur Rahman Crescent Institute of Science and Technology, Chennai-November-2021.
• International conference on current trends and career prospectives in pharmacovigilance and molecular modelling- Priyadarshini College of Pharmacy, 4th March 2023.

FDP’s Attended

• Polymer Matrix-based Nanostructures for targeted drug delivery application- Central Institute of Petrochemicals Engineering and Technology: CSTS GUWAHATI-February 2022
• Material Science and Nano Technology-Department of Chemistry-BS Abdur Rahman Crescent Institute of Science and Technology- August 2020.
• Computer-Aided   Drug   Design-National   Program on   Technology   Enhanced   Learning- September 2019.
• Medicinal Chemistry-National Program on Technology Enhanced Learning-April-2019.

Refresher Course/Orientation Programmes Attended:

• Four weeks Faculty Induction program- Ministry of education, Teaching learning Center Ramanujan College, University of Delhi. From 2o January – 18 Feburary, 2023.

Additional Responsibilities

• Faculty Advisor
• Class Advisor
• Lab Coordinator
• Sports coordinator